Creatine: the most studied supplement in the world (complete guide)

The most researched supplement in history

Creatine monohydrate is, without exaggeration, the most studied sports supplement in scientific literature. The International Society of Sports Nutrition published an updated position paper in 2017 (Kreider et al., Journal of the International Society of Sports Nutrition) reviewing over 500 peer-reviewed studies and concluded that creatine monohydrate is the most effective ergogenic nutritional supplement currently available for increasing high-intensity exercise capacity and lean body mass. A meta-analysis by Branch (2003) of 96 studies showed an average lean mass increase of 1.4 kg compared to placebo when combined with resistance training.

Creatine dosing protocols

There are essentially three dosing protocols backed by science (and one that is not). The standard daily dose is what 90% of users should pick. Loading exists for fast saturation, body-weight scaling for heavier athletes, and cycling is a leftover bro-science myth:

What creatine actually does in your body

Creatine is a molecule naturally produced by your liver, kidneys, and pancreas from three amino acids: arginine, glycine, and methionine. About 95% of your body creatine is stored in muscles as phosphocreatine, where it acts as a rapid energy reserve. During short, intense efforts (lifting heavy, sprinting, jumping), your muscles use ATP, but ATP runs out in 2-3 seconds. Phosphocreatine donates a phosphate group to regenerate ATP, allowing you to do 1-2 more reps per set. Over months, those extra reps translate into more muscle and strength.

• Strength: +5-15% in 1RM compounds (squat, bench press, deadlift)
• Lean mass: +1.0-2.0 kg in 4-12 weeks combined with resistance training
• Anaerobic capacity: +10-15% in repeated sprints
• Cognitive function: improves working memory and reasoning under fatigue (Rae et al. 2003, Proceedings of the Royal Society)
• Bone health: emerging evidence shows benefits in postmenopausal women combined with resistance training

How to take it: the simplest protocol

Forget the complicated loading and cycling protocols you read on bro-science forums. The science is clear and boring: take 3-5 grams of creatine monohydrate every single day, with any meal, with or without water. That is it.

• Type: creatine monohydrate (Creapure brand if available — German pharmaceutical grade). All other forms (HCl, ethyl ester, kre-alkalyn) are more expensive without proven benefits
• Dose: 3-5 grams daily. People over 90 kg may benefit from 5-10 g
• Timing: does NOT matter. A 2013 study by Antonio and Ciccone in JISSN compared pre vs post training and found no difference
• Loading phase: optional. Loading 20g/day for 5-7 days saturates muscles faster, but you reach the same level in 28 days at 3-5g/day
• Cycling: NOT necessary. Your body does not "downregulate" natural creatine production permanently

Myths debunked by 30+ years of research

• MYTH: damages kidneys — FALSE. Multiple long-term studies (Poortmans and Francaux, up to 5 years) show no effect on kidney function in healthy individuals. The slight rise in creatinine on blood tests is from creatine itself, not kidney damage
• MYTH: causes dehydration and cramps — FALSE. A 2003 study by Greenwood in 250 college football players actually found FEWER cramps and dehydration episodes in creatine users
• MYTH: it is a steroid — FALSE. Creatine is a natural compound found in red meat (about 5g per kg of beef). It has no hormonal action whatsoever
• MYTH: you need to cycle it — FALSE. You can take it indefinitely. Studies up to 5 years show no negative effects
• MYTH: makes you bloated — PARTIALLY FALSE. Initial water retention is intracellular (inside the muscle), making muscles look fuller, not puffier

Who should take it (and who should not)

Creatine benefits virtually everyone who does resistance training, anaerobic sports, or wants to preserve muscle mass with age. Vegetarians and vegans see the largest gains because their baseline muscle creatine is lower (no meat in the diet). The only group that should consult a doctor first are people with pre-existing kidney disease.

In Renzy, log your daily creatine in the Wellness section to maintain consistency. The app sends reminders and shows your weekly adherence streak — and consistency is what makes creatine work.